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If A1C levels remain above goal after three months of therapy, a second agent should be added (e.g., sulfonylurea, thiazolidinedione, dipeptidyl-peptidase-4 inhibitor, glucagon-like peptide-1 receptor agonist, insulin)

[1] [2] Exposing an unopened pen to room temperature may compromise the medication's stability and efficacy

In AD, glutamatergic and cholinergic synapses of the temporal lobe are affected first, followed by a spread to other regions (Picconi et al., 2005

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